Epidermal Sensitization to Streptomycin

Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corn...

Determining epidermal disposition kinetics for use in an integrated nonanimal approach to skin sensitization risk assessment.

Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of sensitizer from the applied dose on the skin surface to the epidermis, where innate immune activation occurs. Building on the previous development of...

Streptomycin

ever, certain adjuvants, e.g. para-aminosalicylic acid, may delay the development of drug-resistance. Streptomycin is not absorbed from the alimentary tract and, therefore, it must always be given intramuscularly as well as directly, where possible, into the spaces which it is desired to render free from bacteria. The drug is excreted by the kidney. After intramuscular injection an adequate blo...

Streptomycin

THIS book is a practical guide wlhiclh deals with imiost of the cond(litionis which come wvithin the scope of plastic surgery as practised in the British Isles. The first six chapters arc devoted to basic principles such as the' use of free skin grafts, flaps and tube pedicles, transplantation of tissues othelthan skini and the treatment of wounds, burns, frostbite, scars and(i keloids. The nex...

Streptomycin